This REDTalk explores the multiple knowledge systems of cosmology and the many points of intersection between Indigenous cosmology and Western astronomy. This discussion features cultural astronomers Wilfred Buck (Manitoba First Nations Science Education Resource Centre, Winnipeg) and Michael Wassegiizhig Price (Bemidji State University, Minnesota), astrophysicist Annette S. Lee (St. Cloud University, Minnesota), and astrobiologist Daniella M. Scalice (NASA, Maryland).